Leon Lederman, the author of the book The God Particle (Higgs Boson) originally wanted to call it The Goddamn Particle because the particle was proving very difficult to find, but his publishers thought that this sounded too rude.
Higgs Boson is a particle which is largely responsible for the mass of subatomic particles. It took almost five decades after the particle was first postulated to find it, largely because of the high energy needed to produce it and how quickly it decays into smaller particles.