In October 2020, the newspaper Eje Central wrote that Alejandro Esquer had accompanied Andrés Manuel López Obrador for more than three decades. He was first López Obrador’s secretario particular, private secretary, in 1996. In November 2002, he was named to the post again, when López Obrador was head of government of Mexico City.
Eje Central described his place at the presidency: “Es capaz de abrir espacio en el tiempo del tabasqueño para alguna persona y al mismo tiempo decir no” (He is able to open space in the time of the man from Tabasco for someone, and at the same time to say no). A column in Expansión called him “una de las aduanas para llegar al presidente” (one of the checkpoints on the way to the president).